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Zhou, N, Bott, M, Park, B, Vallieres, E, Wilshire, CL, Yasufuku, K, Spicer, JD, Jones, DR, Sepesi, B, Mitchell, KG, Corsini, EM, Antonoff, MB , Hofstetter, WL, Mehran, RJ, Rice, DC, Swisher, SG, Vaporciyan, AA, Walsh, GL, Huynh, C, Fiset, PO, Chun, SG, Gay, CM

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3.6.2 Cellular signaling modification The formation of DTP cells and drug resistance are closely related to the alteration of various signaling pathways, such as EGFR, JAK/STAT, PI3K/AKT, MAPK and other signaling pathways (103, 104)

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Supporting regional vulnerability further, another study reported that GPX4 is present within dystrophic dopaminergic axons in the putamen of PD brains, suggesting increased ferroptotic stress in this region as well [42]

doi:10.1038/sj.onc.1210796 Harris IS, Treloar AE, Inoue S et al (2015) Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression