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VEGF-intercellular crosstalk within the TME The TME, consisting of a complex network of cells, including CCs, immune cells, fibroblasts, and ECs along with the ECM components acts cumulatively to influence cancer growth, progression, and response to therapy [86]

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Compared to people with the CC genotype and normal riboflavin levels, the study found that those with the TT genotype had a 1.6 and 3 times higher risk of having high blood pressure (hypertension) if they were deficient or low in riboflavin, respectively