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In a recent interventional study, 80 first-episode drug-naive patients with BD who received psychotropic therapy supplemented with either probiotic or placebo were followed up for 3 months for observing clinical symptom improvements and changes in oxidative stress markers [305]

Nevertheless, whether it is chemotherapy, targeted therapy or immunotherapy, there exists widespread drug resistance, which can hinder the treatment of tumours and cause disease recurrence (2)

Mixing an approved drug with an investigational compound is the standard safety position

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