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Accordingly, in experimental models, supplements of omega-3 PUFAs have been demonstrated to exert neuro-protective and cardio-protective effects against hypothyroidism-induced damage, while attenuating hyperthyroidism-associated complications, including arrhythmias and hepatic dysfunction, thereby conferring protective actions on peripheral tissues across opposing states of thyroid dysfunction [127,130,131,132]

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Hippocampal neurons require a large pool of glutathione to sustain dendrite integrity and cognitive function

Any pathological process that can disrupt these interconnected metabolic hubs, such as mitochondrial dysfunction in PD or oxidative stress in AD, may inadvertently lower the cellular threshold for resistance to ferroptosis