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Phospholipids incorporating PUFAs contain unstable bis-allylic hydrogen atoms, making them highly susceptible to lipid peroxidation, which in turn drives the execution of ferroptosis [15]

Genes Cells Devoted Mol Cell Mech

The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site)

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GGT activity (d) (n = 6 technical replicates from 3 independent experiments) and cell numbers (e) (n = 3 technical replicates for Cys 2 -free or n = 6 technical replicates for Control or Cys 2 -free + GSH from 3 independent experiments) for cells grown in control (208 M cystine

It may be attributed to inhibition of ghrelin secretion, which leads to increased adiponectin levels 47