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To further assess the penetration and targeting efficiency of protein-based nanodrugs in plaque lesions, aortic root sections were embedded in optimal cutting temperature compound (Fisher Scientific) and cryosectioned at 8 m using a cryostat microtome (CM1860, Leica)

& Sarnyai, Z

This represents a major escalating public health challenge for the decades ahead

Moreover, a recent single-nuclei multiomic study that profiled gene expression and chromatin accessibility of young, aged and PD human postmortem midbrain samples showed that OLs were both the major cell type in the midbrain and one of the most altered cell types in PD, and identified a disease-associated OLs subpopulation (Adams et al., 2024)

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We theorized that the homeostatic balance of mitochondria would require increased mitophagy to accompany this upregulation in mitochondrial biogenesis