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The pentapeptide PHTrP107-111 (osteostatin), which includes the Thr-Arg-Ser-Ala-Trp sequence from the C-terminal fragment of PTH-related proteins, promotes osteogenic differentiation of MSCs, inhibits senescence and inflammation in osteoarthritic osteoblasts, reverses skeletal alterations associated with IGF-1 deficiency, and improves bone regeneration in animal models of bone defects [95, 96]

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