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However, in senescent CD8 T cells, autophagy is not restored despite reduced mTORC1 activity, partly due to alternative inhibitory mechanisms such as chronic p38 MAPK activation, which impairs autophagy independently of mTORC1 and contributes to immune decline in senescent CD8 T cells

BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia

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10.1038/nmeth945

DNA methylation and histone methylation are both epigenetic modifications that affect gene expression without altering the DNA sequence

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