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Via erastin-treated HT 1080 cells by RNA-Seq and RT-qPCR, the upregulation of the ER stress response gene cation transport regulator homolog 1 (CHAC1) was validated to be a significant pharmacodynamic marker of system xc- inhibition and a transcriptional PD marker for exposure to erastin and other agents that deplete cells of cystine or cysteine [83, 224, 225]

AdipoQ is a novel adipose-specific gene dysregulated in obesity

doi:10.1016/ 0003-9861(63)90179-6 Tan, B., Li, X

Masaoka, A., Horton, J