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(due to 1st pass effect) Not effective orally Hepatic metabolism, half life 1.5-2 hrs (this can result in CNS toxicity) Patients with CHF or hepatic disease will have higher plasma levels Major drug Interactions: MAOIs or ergot alkaloids (when using epinephrine containing solutions)

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The FDAs current safety page continues to cite concerns about immunogenicity, peptide impurities and limited safety data, and the agency has stated that a substance may still pose significant safety risks

Visual Characteristics of Lyophilized Ipamorelin Depending on manufacturing conditions and freeze-drying parameters, lyophilized Ipamorelin may appear as: Fine white powder White or off-white lyophilized cake Compact peptide puck adhered to the vial surface Minor variations between vials are normal and generally reflect differences in freeze-drying parameters, formulation composition, or vial geometry during manufacturing

974-977 Esposito, P., et al., 2003

Additional information FDA Disclaimer: The statements made regarding these products have not been evaluated by the U.S