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In vitro , NAR has been found to reduce intracellular MDA levels and ROS accumulation while upregulating the antioxidant gene NRF2, indicating its ability to alleviate oxidative stress and chondrocyte damage induced by iron overload (Pan et al., 2022)

References 1 BrayFLaversanneMSungHFerlayJSiegelRLSoerjomataramIet al

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Prieto 1993

In this context, the resulting effects of melatonin actions on mood must be understood as a more complex and multifactorial pattern of systemic regulation, rather than an antidepressant effect per se