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For example, in colorectal cancer, p53 non-transcriptionally inhibits dipeptidyl peptidase 4 activity to prevent Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-mediated lipid peroxidation and erastin-induced ferroptosis, whereas TP53 deficiency enhances this process [46,47]

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After standard PK, patients can become tolerant to contact lens wear for varying periods (212 h per day), in about 50% of cases 53

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