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Johansson and Hansson 2016

Oral peptides: Most peptides marketed as oral supplements (gummies, capsules) have poor bioavailability because the digestive tract breaks them down

The supportive evidence goes for both bipedal and quadrupedal rat positions

Place learning (Day 1721): all doors remained closed, but access to water was restricted to one water-rewarded corner (the individual least preferred corner during nose poke adaptation) termed the correct corner. Three successive nose pokes at the individual correct corner opened the respective door for 5 s

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Additionally, non-invasive options to alleviate patient burden and enhance compliance, such as eye drops or systemic medications, are essential