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The primary metabolite of ifosfamide, aldoifosfamide, is also a substrate for aldehyde dehydrogenase, and this is consistent with low toxicity of the drug to the bone marrow and the GI tract due, as mentioned previously with cyclophosphamide, to the presence of high levels of the enzyme in these organs

Notably, the NOX family, the only enzymes specifically dedicated to ROS generation, plays a crucial role in the pathogenesis of DCM

doi: 10.3390/ijms23147722 91

GSH is a peptide, made up of amino acids

Glutathione is a powerful antioxidant that is naturally produced in the body