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Studies have shown that changes in the gut microbiota down-regulate the expression of tight junction (TJs) proteins, leading to impaired intestinal barrier and bloodbrain barrier function, allowing biomacromolecules and microorganisms to penetrate the barrier, which in turn triggers neuroinflammatory responses (118)

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It should be administered in liquid or powder form, following the recommended dosage, but avoided in pregnant or lactating dogs.The usually recommended extract of milk thistle contains 70 to 80% silymarin

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