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and (3) increased Nrf2 levels in lung tissues to prevent ubiquitination or deubiquitination of Nrf2, thereby facilitating its nuclear translocation and inhibiting ferroptosis

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Ritlecitinib Ritlecitinib 50mg once daily (oral capsules) is the first highly selective covalent inhibitor of the JAK3/TEC kinase family,10 and the only one approved for use in patients aged 12 years

239 Mitochondrial iron accumulation lead by Fe-S cluster deficiency can further induce iron-mediated ROS increasing and subsequent ferroptosis that due to lipid peroxides accumulation

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doi: 10.1016/j.clinme.2024.100030 [PubMed] 39407841 Scafetta T, Kovacs O, Milani GP, Bronz G, Lava SAG, Betti C, Vanoni F, Bianchetti MG, Far PB, Camozzi P