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They typically start with history, symptoms, and ruling out more common causes (sleep disorders, thyroid issues, depression/anxiety, overtraining, medication effects)

Nature 433 , 613617 (2005)

Clin Physiol Biochem 8: 204210

Therefore, while PDOs serve as an invaluable tool for understanding the intrinsic properties of chemoresistant tumor cells, they cannot fully capture the extrinsic factors that contribute to resistance