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To better understand the mechanism of HO-1 action in VaD and its potential therapeutic value, future investigations should be directed toward the following objectives: (1) clarifying the specific mechanisms of HO-1-derived metabolites and comparing their effects across various disease models

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Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators

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A large proportion of cancer cells experience high levels of oxidative stress (51,52), which indicates that increasing cysteine through de novo biosynthesis or protein metabolism cannot satisfy the high demand for antioxidant defense in cancer cells

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