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After consideration of public comments, we are increasing both our one-time and ongoing annual burden estimates as demonstrated in section XXIII

Through a series of structure-activity relationship (SAR) studies, the authors optimized the peptide sequence and introduced a C20 fatty diacid via a -glutamic acid linker to the N-terminus

Acknowledgements The authors would like to acknowledge Carlos Martn and Nacho Aguil for the critical reading of the manuscript

Pet insurance [can] mitigate costs, but pet owners expressed frustration over the high premiums and question whether insurance is worth the cost for aging pets (Theme 3: Pet insurance and budgeting in Section 3.5.4)

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