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3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy

DGBP decreases levels of active Rac As we observed that DGBP treatment strongly decreased levels of membrane-associated Rac (Figure 3), we assessed how DGBP treatment affects Rac activation as monitored by its GTP binding

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16G: Commonly used in ICUs and surgery to quickly replace significant fluid or blood loss

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