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Disclosures: Cara Mack: Nothing to Disclose, Yuhuan Luo: Nothing to Disclose, Julia Jezykowski: Nothing to Disclose, Lisa Fraser: Nothing to Disclose, Nitika Gupta: Nothing to Disclose, Alexander Miethke: Mirum Pharmaceutical Inc: Grant/Research Support, Mirum Pharmaceutical Inc: Consultant, Ipsen: Speaking and Teaching, Sarah Taylor: Mirum Pharmaceuticals: Consultant, Ipsen Pharmaceutical: Consultant, Mirum Pharmaceutical: Consultant, Estella Alonso: Nothing to Disclose, Simon Horslen: Nothing to Disclose, Rohit Kohli: Mirum: Consultant, Ipsen: Consultant, Epigen: Grant/Research Support, Sanofi Rare Disease: Consultant, Jean Molleston: Gillead: Grant/Research Support, Albireo: Grant/Research Support, Abbvie: Grant/Research Support, Mirum/Shire: Grant/Research Support, CF FOundation: Grant/Research Support, Binita Kamath: Mirum: Consultant, Mirum: Grant/Research Support, Albireo/Ipsen: Consultant, Albireo/Ipsen: Grant/Research Support, Audentes: Consultant, Stephen Guthery: Nothing to Disclose, Kathleen Loomes: Mirum: Consultant, Albireo/Ipsen: Consultant, Mirum: Clinical trials, Albireo/Ipsen: Clinical trials, John Magee: Nothing to Disclose, Philip Rosenthal: Nothing to Disclose, Pamela Valentino: Grifols: Advisor, Mirum: Speaking and Teaching, Ronald Sokol: Nothing to Disclose 2477 EXTRACELLULAR VESICLE MIRNA ANALYSIS FROM ADOLESCENTS WITH MASLD WITH AND WITHOUT OBSTRUCTIVE SLEEP APNEA/CHRONIC INTERMITTENT HYPOXIA Shikha Sundaram 1 Swati Ghosh 1 Alexander Chaidez 1 Ronald Sokol 2 , 1 Children's Hospital Colorado, 2 University of Colorado School of Medicine Background: Metabolic Associated Steatotic Liver Disease (MASLD) is the predominant cause of chronic liver disease in children

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Notwithstanding encouraging existing accomplishments, there are only a few investigations that reveal EXOs to be superior to FDA-authorized nanomedicines (e.g., liposomes)

Protective mechanisms of anthocyanins from purple sweet potato against tertbutyl hydroperoxideinduced hepatotoxicity

Therefore, Azgp1 is significantly correlated with downstream lipid metabolic pathways mediated by mTOR