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BMJ 334 , 201205 (2007)

Reactions were performed with 5 M histone H3 (histone L-arginine) substrate, 1 M radiolabeled S-adenosyl-L-[methyl- 3 H] methionine (SAM) co-substrate, and recombinant human PRMT3 enzyme

If the diagnostic workup identifies a sleep disorder as a possible cause for daytime sleepiness, an etiology-driven therapeutic approach according to the guidelines summarized above is recommended

[2] Patients should follow precise dosing instructions and avoid self-titration without healthcare provider guidance

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