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Since the drug candidate has already been translated into the clinic for several decades, its established pharmacological properties and safety and side-effect profiles expedite preclinical and clinical assessment for the treatment of COVID-19

Angelini et al

doi: 10.1111/jcmm.13141 89 YuanXTongBDouYWuXWeiZDaiY

Nelson DA, Niu J, Mitchell KG, Vaporciyan AA, Hofstetter WL, Antonoff MB , Giordano SH, Sepesi B, Mehran RJ, Rice DC

Arsikin K, Kravic-Stevovic T, Jovanovic M et al (2012) Autophagy-dependent and -independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cells

Mice injected with 55 mg/kg EGCG exhibited hepatotoxic effects but survived the duration of the study (229)