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However, it is unclear if there is bidirectional link between ACE2 levels and increased redox cellular pathways in the setting of SARS-CoV-2-induced ACE2 downregulation in airway epithelial cells

Animals were controlled daily for clinical symptoms and detection of adverse events to ensure compliance with animal welfare

Together, these results suggest that GTP is heavily used in autophagy and that 3xTg-AD neurons lose the capacity to respond to autophagic induction

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Mechanistic studies using two animal modelsimmunodeficient Nu/Nu mice (Fig