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The levels of glutathione depend on the mutation in question, and nrc1 , cad2-1 , pad2-1 and zir1 , which are affected in GSH1 show glutathione levels that range from 45 to 15% of normal levels 50,51,54,68

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In the central nervous system, FPN1 is distributed in most cell types, including neurons, astrocytes, oligodendrocytes, and brain microvascular endothelial cells (Bao et al., 2021).In neurons, amyloid precursor protein (APP) connects to FPN1 and stabilizes the expression level of FPN1