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The main derivatives of astragalus are methylxanthine, theophylline (1,3-dimethylxanthine), theobromine (3,7-dimethylxanthine), and caffeine (1,3,7-trimethylxanthine) (Li et al., 2017)

The introduction of a single His residue into human GSH transferase A1-1 created an unprecedented enzymatic function, suggesting a strategy that may be of broad applicability in the design of new enzymes

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The activation of de novo ser/gly synthesis pathway has been observed, both because of serine synthesis gene amplifications and alterations of upstream regulators that promote enhanced enzyme overexpression

27 , gaab067 (2021)