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Finally, the only approved drug to treat ALS, which increases survival by 23 months (Miller et al., 2012), acts as an inhibitor of NMDA and kainate receptors (Debono et al., In autopsied spinal cord from patients with ALS, several groups reported a pronounced reduction of EAAT2 but not EAAT1 protein expression in the gray matter in areas with significant motor neuron loss (Sasaki et al., 2000)

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Selenium-containing small molecules, such as ebselen and its analogues, have also exhibited important antioxidant activity as GPx mimics 12,13,14,15