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Importantly, it has been proposed that the up-regulation of autophagy could work as a therapeutic target to treat these diseases (Thellung et al., 2018), and autophagy stimulation has been shown to significantly suppress HSV-1 infection in various cell types, as evidenced by assessing HSV-1 genomes and virus titers that indicated that inducing autophagy strongly suppresses HSV-1 infection (Yakoub and Shukla, 2015)

10.1093/burnst/tkac022 48 WangJ.FuY.HuangW.BiswasR.BanerjeeA.BroussardJ

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