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People with impaired liver or kidney function should use it with caution

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Though the drug is a diuretic agent that can assist horses in excreting up to 20 to 30 pounds in urine on race day and may have some impact on total circulating blood volume, it likely has an effect on the ability of vessels within the lungs to relax and accommodate greater volume expansion as well

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, 131 , 356-369, doi: Wu, Z., Geng, Y., Lu, X., Shi, Y., Wu, G., Zhang, M., Shan, B., Pan, H., and Yuan, J