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The CROP-seq experiments were carried out similarly as previously described 3

Any therapeutic use occurs under physician supervision as off-label research application requiring comprehensive informed consent, medical monitoring, and understanding that the peptide is not an approved pharmaceutical agent

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For comparison, the modified GHRH analog CJC-1295 (specifically the version without DAC, which is what is commonly used in modern clinics) has a longer functional duration that keeps the GHRH stimulus present long enough for a more meaningful, sustained growth hormone pulse to occur

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