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Description

MDA-MB-468 xenograft model MDA-MB-468 cells are characterized by their triple-negative status, cells do not express the estrogen receptor (ER), progesterone receptor (PR), or HER2

We followed up on two hits that exhibited the strongest GxE interactions, SLC25A19 and SLC25A32, which are transporters of two B family vitamin-derived cofactors, thiamine pyrophosphate (ThPP, or vitamin B 1 ) and folate species (vitamin B 9 ), respectively

Bicarbonate or buffering agents for metabolic acidosis (due to elevated lactate or ketosis) at 0.5 to 2.5 mEq/kg/day is necessary for individuals with pyruvate dehydrogenase complex deficiency, particularly those on ketogenic diet

Supplementary Materials Data Availability Statement The raw data supporting the conclusions of this article will be made available by the authors on request.