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Diabetic wound healing studies using collagen dressings with GHK demonstrated 9-fold increase in collagen synthesis in healthy rats with higher glutathione and ascorbic acid levels, better epithelialization, and activation of fibroblasts and mast cells

Moreover, animal studies have shown that complete inhibition of BACE1 activity results in an elimination of A in neurons, but A is required for certain physiological neuronal functions such as regulation of neuron-glia signaling by enhancing spontaneous astrocyte calcium transient signaling via 7-nAChRs (Lee et al., 2014), activation of M2 microglia cells after SCI promoting plasticity, axonal outgrowth and inhibition of inflammation (Kigerl et al., 2009