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The protective effect of PPAR agonists against APAP-induced toxicity emphasizes the importance of fatty acid metabolism in this process (Patterson et al

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[7]Current Patent Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY - KR101893879, 2018, B1 Location in patent: Paragraph 0287-0290

Notably, treatment with broad-spectrum oral antibiotics partially diminished the protective efficacy of HABN against DSS-induced colitis, underscoring the role of microbiota in mediating these effects

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[30] One of the most potent flavonoids in senotherapy, fisetin, when administered late in life in wild type mice, reduced senescence burden across multiple organs in vivo , improved tissue homeostasis, alleviated age-related pathologies and led to increased median and maximum lifespan