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Studies also showed that low serum levels of vitamin D and zinc are associated with poor outcomes in patients with COVID-19 (158) and a good vitamin D status may have beneficial effects on the course of the disease (177, 178)

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pQCT data possibly suggested the cortical BMC boost could be due to a larger bone cross-section, while the cortical volumetric BMD (bone volume density) might have stayed stable

The changing expression of SMAD6 and SMAD1, their localization predominantly to vascular endothelial cells, and the roles of ACVRL1 and ENG in angiogenesis support the hypothesis of aberrant tissue remodeling in the lung vasculature during emphysema pathogenesis

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Understanding these pathways establishes a basis for therapeutic interventions, such as targeted ion channel inhibitors, antioxidant treatments, and enhanced storage solutions designed to prolong the lifespan and quality of transfused RBCs (11, 36, 37)