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Levels of tGSH in the TIF were much higher than reported amounts added to formulations of cell culture media (Extended Data Fig

2 Preclinical evidence and mechanistic studies This section summarizes the key in vitro and in vivo findings from preclinical studies of major classes of natural metabolites from TCMs with cardioprotective effects, and discusses the key molecular targets and pathways by which these natural metabolites exert their cardioprotective effects

Gualtieri R, Kalthur G, Barbato V, Di Nardo M, Adiga SK, Talevi R

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Glutathione synthesis is regulated by nitric oxide in Medicago truncatula roots