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They further demonstrated that EGLN1 and c-Myc directly activated the expression of LSH by inhibiting HIF-1 (Jiang et al., 2017b)

[DOI] [PMC free article] [PubMed] [Google Scholar] 184.Romeo J, Daz L, Gonzlez-Gross M, Wrnberg J, Marcos A

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11 Ghrelin Receptor (GHS-R1a) PharmacologyGhrelin / GHS-R1a receptor signalling and growth-hormone secretagogue mechanism of action

After equilibrated with molecular dynamics (MD) simulation, the final structure of GSDME was employed for molecular docking, where the docking center was set to each predictive Cys site (a total of 13 Cys sites) of the protein