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The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]

However, that is not its only benefit, it plays a vital role in other bodily functions as well

If you are deficient in vitamin B12, you may get anaemia

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NAD+ drives cellular energy and mitochondrial function