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In normal prostate cells IGF-1 maintained differentiated cellular characteristics, however in prostate cancer cells it induced a mesenchymal phenotype ( Summary The interconnected IGF/IGFR and sex steroid signalling pathways play crucial roles in normal growth and development and their perturbation is often associated with diseases of metabolism

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Journal of Clinical Endocrinology & Metabolism (2011) 6

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Population specificity

Anyone claiming dramatic physical transformation in the first two weeks is either exaggerating, responding to placebo effect, or attributing unrelated changes to the peptides