how to calculate reduction potential glutathione oxidation and reaction in relation L-Glutathione vs. oxidized vs. Reduced

A retrospective study looking at concomitant use of proton pump inhibitors (PPIs) alongside metformin in 614 people with type 2 diabetes in the US found a significant reduction in B12 levels of 34% in patients taking both medications, compared to controls taking either drug alone (Long et al, 2012)

*Clinical response=reduction in complete Mayo score of 3 points and 30% from baseline with an accompanying decrease in rectal bleeding subscore of 1 point or absolute rectal bleeding subscore of 1 point

Hydrogen peroxide- and glutathione-associated mechanisms of acclimatory stress tolerance and signaling

Cell 87 , 10251035 (1996)

1F and Figure S1E)

Results: Of the 3706 participants, 397 (11%) underwent MRI and were included in this analysis