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Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection ( 4.6 Overcoming challenges in translating natural compounds into clinical applications Despite promising findings, translating the therapeutic potential of natural compounds into clinical practice presents several key challenges

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Localised iron overload has been associated with several neurodegenerative diseases (i.e., Alzheimers disease and Parkinsons disease), based on measurements of elevated brain iron, demonstrated through magnetic resonance imaging (MRI) imaging [23-25] , ferritin in cerebrospinal fluid (CSF) [26,27] , and postmortem analyses [28-30]

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