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Notably, the amount of fasting-induced c-Fos-positive cells in the ARH was reduced in AgRP GHR KO mice (Fig

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Although insulin and IGF-I share many similarities, during evolution, the functionality of the two molecules has become more divergent, where insulin plays a more metabolic role and IGF-I plays a role in cell growth

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Notably, AKT kinase activity is cell cycle regulated, and begins to increase in late G1-phase [51]