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Sirtuin 3 has the capacity to catalyze the deacetylation of mitochondrial SOD2, which in turn increases the scavenging efficiency of O 2 in mitochondria

10.1038/s41380-022-01842-x [DOI] [PMC free article] [PubMed] [Google Scholar] Bercik P., Denou E., Collins J., Jackson W., Lu J., Jury J., et al

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The size, shape, and deformability of erythrocytes are crucial to their function, and abnormalities in these traits are seen in conditions like rheumatoid arthritis and T2DM

Thromb Haemost 113:494504 Papp LV, Lu J, Holmgren A, Khanna KK (2007) From selenium to selenoproteins: synthesis, identity, and their role in human health

Similarly, the flavonoid calycosin, which also possesses antioxidant and anti-inflammatory properties, prevents high glucose-induced cell ferroptotic damage by upregulating the GSH/GPX4 pathway in human renal proximal tubular epithelial cells (HK-2 cells), reducing LPO, and inhibiting the expression of nuclear receptor coactivator 4 (NCOA4) (141)