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In contrast to sperm capacitation, acrosome reaction is an irreversible process which involves the release of acrosomal hydrolytic enzymes to attain sperm oocyte fusion (82)

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The hallmark features of AD include the accumulation of amyloid-beta (A) and the formation of neurofibrillary tangles in the brain 1

Based on the above mechanism, combined therapeutic strategies targeting the T cell-ferroptosis axis have shown clinical potential: radiotherapy synergizes with immunity, and radiotherapy-induced ATM activation synergistically inhibits SLC7A11 expression with IFN- released by CD8+ T cells, significantly increasing lipid peroxidation levels and thus significantly enhancing the therapeutic effect of ferroptosis (223)

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In a small pilot study of 6 healthy volunteers who were undergoing screening colonoscopy, patients who received PEG in addition to 10 grams of vitamin C had 35% greater stool volume compared to those who had the standard of care PEG alone (2.2 L vs