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Conversely, other studies revealed that the decreased survival of cancer patients is associated with the suppressed expression of GPx2, confirming the tumor-suppressive function of GPx2 (Ren et al

Hence, there is growing support for the use of compounds that target only peripheral opioid receptors, avoiding the central nervous system, which helps to reduce the risk of common opioid-related side effects

Recently, it was shown that atrial overexpression of gp91 phox -containing NAPDH oxidases (NOX2), the activity of which is upregulated in the atria in AF and represents the predominant sources of atrial O 2 - , does not contribute to atrial electrical or structural remodeling parameters in mice and has modest effects on AF inducibility but no effect on AF duration [70,71]

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Kernan J, Bonacci T, Emanuele MJ

Ensemble-based virtual screening led to the discovery of new classes of potent tyrosinase inhibitors