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Especially Per2 and BMAL1 genes have been more pronounced as tumor suppressors (Li et al., 2017

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found that an engineered alternative scaffold protein [affibody molecule (Z FcRn )] effectively blocked the IgG-FcRn interaction when repeated injections of Z FcRn and Z FcRn fused to an albumin binding domain (ABD) in mouse models led to a 40% reduction of IgG in serum (88)