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Additionally, inflammatory mediators in the bone microenvironment amplify local RANKL/RANK signaling, linking systemic and localized immune responses to bone pathology (44)

Nonetheless, the practical implementation of FMT encounters numerous challenges due to the influence of various confounding factors on the treatment process

Treatment of UC involves conserving stable remission, to reduce relapses and prevent the development of colitis associated cancer via targeting the immune response and proinflammatory factors [Citation3]