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TGF- pathway Ionizing radiation-induced ROS activate latent TGF-1 by oxidizing Met253 in its LAP, triggering conformational changes, suggesting the isoform specificity of ROS in TGF- activation

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It has been shown that following a Mediterranean diet (the PREDIMED [Prevencin con DIeta MEDiterrnea] intervention) can lead to an increase in plasma total antioxidant capacity (or non-enzymatic antioxidant capacity, NEAC) (Zamora-Ros R et al., 2013)

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GDH promotes the metabolism of glutamate and glutamine to generate ATP, which is profoundly increased in multiple human cancers