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To this day, several clinical trials are ongoing in a large panel of age-related diseases, but their validation remains uncertain (Table 1)

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The Evidence Base: What Human and Animal Studies Actually Show Translating rodent data to human protocols requires caution, but the MOTS-c literature offers enough cross-species convergence to draw meaningful clinical inferences

While they share some overlapping areas of investigation, they differ significantly in structure, origin, and proposed mechanisms

Then, in June, the remaining employees were gathered again for more news: Caldwell and Cunningham were no longer with the university

They are not approved for human or veterinary administration, are not evaluated by the FDA or EMA, and must not be used as drugs, supplements, or cosmetic products