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The FIC index is calculated as FIC + FIC = (MIC of drug A in combination / MIC of drug A alone) + (MIC of drug B in combination / MIC of drug B alone)

Psychiatry 76, 725733

In vitro experiments demonstrated that resveratrol activates the SIRT1/Nrf2-ARE antioxidant pathway, thereby inhibiting the aberrant proliferation of RA-FLSs and inducing a significant increase in apoptosis