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Beyond energy production, NAD+ is also crucial for supporting DNA repair[1][2], regulating inflammation[2] and maintaining mitochondrial function[2]

doi: 10.1111/andr.12655 40 De RosaMZarrilliSPaesanoLCarboneUBoggiaBPetrettaMet al

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Gastrointestinal Toxicities Gastrointestinal toxicities are the second most common irAEs observed with ICI therapy, and they range from mild diarrhea to severe colitis and intestinal perforation, which can lead to death (Cramer & Bresalier, 2017